Kev ua haujlwm zoo ntawm melatonin yog txhawm rau txhim kho kev pw tsaug zog zoo (ntau npaum li 0.1 ~ 0.3mg), ua kom lub sijhawm tsaug zog thiab tsaug zog ua ntej pw tsaug zog, txhim kho kev pw tsaug zog zoo, txo qis tus naj npawb ntawm kev tsaug zog thaum pw tsaug zog, txo lub teeb pw tsaug zog, ua kom ntev. lub sijhawm pw tsaug zog, thiab txo qis qhov pib sawv ntxov nyob rau yav sawv ntxov.Nws muaj zog lub sij hawm sib txawv hloov ua haujlwm.
Cov yam ntxwv loj tshaj plaws ntawm melatonin yog tias nws yog qhov muaj zog tshaj plaws endogenous dawb radical scavenger pom txog tam sim no.Lub luag haujlwm tseem ceeb ntawm melatonin yog koom nrog hauv cov kab mob antioxidant thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative.Hauv qhov no, nws txoj kev ua tau zoo tshaj tag nrho cov tshuaj paub hauv lub cev.Cov kev tshawb fawb tshiab kawg tau ua pov thawj tias MT yog tus thawj coj ntawm endocrine, uas tswj cov kev ua ub no ntawm ntau cov qog endocrine hauv lub cev.Nws muaj cov haujlwm hauv qab no:
Tiv thaiv kev hloov pauv pathological
Vim tias MT yooj yim nkag mus rau hauv hlwb, nws tuaj yeem siv los tiv thaiv DNA DNA.Yog tias DNA puas lawm, nws tuaj yeem ua rau mob qog noj ntshav.
Yog tias muaj Mel hauv cov ntshav txaus, nws tsis yooj yim rau mob qog noj ntshav.
Kho circadian atherosclerosis
Lub secretion ntawm melatonin muaj ib tug circadian atherosclerosis.Tom qab tsaus ntuj, lub teeb stimulation tsis muaj zog, enzyme kev ua ntawm melatonin synthesis nyob rau hauv lub caj pas pineal nce, thiab qib secretion ntawm melatonin nyob rau hauv lub cev nce ntxiv, mus txog lub ncov ntawm 2-3 teev sawv ntxov theem ntawm melatonin thaum hmo ntuj ncaj qha cuam tshuam qhov zoo. ntawm pw tsaug zog.Nrog rau kev loj hlob ntawm lub hnub nyoog, lub caj pas pineal shrinks kom txog rau thaum calcification, ua rau lub cev tsis muaj zog lossis ploj ntawm lub suab ntawm lub moos lom neeg, tshwj xeeb tshaj yog tom qab 35 xyoo, qib ntawm melatonin secreted los ntawm lub cev poob qis, nrog qhov nruab nrab ntawm 10. -15% txhua 10 xyoo, ua rau pw tsaug zog tsis zoo thiab ua haujlwm tsis zoo.Qhov txo qis ntawm melatonin qib thiab pw tsaug zog yog ib qho ntawm cov cim tseem ceeb ntawm tib neeg lub hlwb kev laus.Yog li ntawd, cov tshuaj ntxiv ntawm melatonin hauv vitro tuaj yeem tswj hwm qib melatonin hauv lub cev hauv lub xeev hluas, kho thiab kho cov circadian atherosclerosis, uas tuaj yeem tsis tsuas yog tsaug zog, tab sis kuj txhim kho lub neej zoo, txhawm rau txhim kho kev pw tsaug zog zoo, Nws yog ib qho tseem ceeb dua los txhim kho lub xeev kev ua haujlwm ntawm tag nrho lub cev, txhim kho lub neej zoo thiab ncua cov txheej txheem ntawm kev laus.
Melatonin yog ib hom tshuaj hormones uas tuaj yeem ua rau pw tsaug zog.Nws tuaj yeem kov yeej kev pw tsaug zog tsis zoo thiab txhim kho kev pw tsaug zog zoo los ntawm kev tswj hwm ntuj tsaug zog.Qhov sib txawv loj tshaj plaws ntawm melatonin thiab lwm yam tshuaj tsaug zog yog tias melatonin tsis muaj kev quav tshuaj thiab tsis muaj kev phiv tshwm sim.Noj 1-2 ntsiav tshuaj (kwv yees li 1.5-3mg melatonin) ua ntej yuav mus pw thaum hmo ntuj feem ntau tuaj yeem ua rau qaug zog li ntawm 20 mus rau 30 feeb, tab sis melatonin yuav cia li poob kev ua haujlwm tom qab kaj ntug thaum sawv ntxov, Tom qab sawv, yuav tsis muaj kev xav. nkees, tsaug zog thiab tsis tuaj yeem sawv.
ncua kev laus
Lub caj pas pineal ntawm cov neeg laus maj mam txo qis thiab qhov tso tawm ntawm Mel sib raug zoo zuj zus.Qhov tsis muaj Mel xav tau los ntawm ntau yam kabmob hauv lub cev ua rau kev laus thiab kab mob.Cov kws tshawb fawb hu lub caj pas pineal lub cev "lub sijhawm laus."Peb ntxiv Mel ntawm lub cev, thiab tom qab ntawd peb tuaj yeem tig rov qab lub sijhawm laus.Thaum lub caij nplooj zeeg xyoo 1985, cov kws tshawb fawb tau siv cov nas uas muaj hnub nyoog 19 hli (65 xyoo hauv tib neeg).Kev ua neej nyob thiab zaub mov ntawm pawg A thiab pab pawg B yog tib yam nkaus, tshwj tsis yog tias Mel tau ntxiv rau cov dej haus ntawm pawg A thaum hmo ntuj, thiab tsis muaj tshuaj ntxiv rau cov dej haus ntawm pawg B. Thaum xub thawj, tsis muaj qhov sib txawv ntawm ob pawg.Maj mam, muaj qhov sib txawv amazing.Cov nas nyob rau hauv pawg B tswj tau muaj kev laus pom tseeb: cov nqaij pob txha ploj, cov pob khaus npog ntawm daim tawv nqaij, dyspepsia thiab cataract hauv qhov muag.Tag nrho cov nas nyob hauv pab pawg no laus thiab tuag.Nws zoo kawg nkaus uas pab pawg A nas uas haus dej Mel txhua hmo ua si nrog lawv cov xeeb ntxwv.Tag nrho lub cev muaj cov plaub hau tuab, ci ntsa iab, kev zom zaub mov zoo, thiab tsis muaj kab mob cataract hauv qhov muag.Raws li rau lawv lub neej nruab nrab, cov nas nyob rau hauv pab pawg B txhua tus raug kev txom nyem ntau tshaj 24 lub hlis (sib npaug rau 75 xyoo ntawm tib neeg);Qhov nruab nrab lub neej ncua ntawm nas nyob rau hauv pawg A yog 30 lub hlis (100 xyoo ntawm tib neeg lub neej).
Regulatory nyhuv ntawm central paj hlwb
Ntau cov kev tshawb fawb soj ntsuam thiab kev sim tau pom tias melatonin, uas yog endogenous neuroendocrine hormone, muaj kev ncaj ncees thiab tsis ncaj physiological kev tswj ntawm lub hauv paus paj hlwb, muaj kev kho mob rau pw tsaug zog mob, kev nyuaj siab thiab kab mob hlwb, thiab muaj kev tiv thaiv ntawm paj hlwb. .Piv txwv li, melatonin muaj cov nyhuv sedative, tuaj yeem kho kev nyuaj siab thiab kev puas siab puas ntsws, tuaj yeem tiv thaiv cov hlab ntsha, tuaj yeem txo qhov mob, tswj kev tso tawm cov tshuaj hormones los ntawm hypothalamus, thiab lwm yam.
Kev tswj ntawm lub cev tiv thaiv kab mob
Neuroendocrine thiab lub cev tiv thaiv kab mob sib cuam tshuam.Kev tiv thaiv kab mob thiab nws cov khoom tuaj yeem hloov pauv kev ua haujlwm ntawm neuroendocrine.Neuroendocrine signals kuj cuam tshuam rau kev tiv thaiv kab mob.Nyob rau hauv kaum xyoo tsis ntev los no, kev tswj cov nyhuv ntawm melatonin ntawm lub cev tiv thaiv kab mob tau nyiam thoob plaws lub ntiaj teb.Cov kev tshawb fawb hauv tsev thiab txawv teb chaws qhia tias nws tsis tsuas yog cuam tshuam rau kev loj hlob thiab kev loj hlob ntawm lub cev tiv thaiv kab mob, tab sis kuj tswj hwm kev tiv thaiv kab mob humoral thiab cellular, nrog rau cytokines.Piv txwv li, melatonin tuaj yeem tswj hwm cellular thiab humoral kev tiv thaiv, nrog rau cov dej num ntawm ntau yam cytokines.
Kev tswj ntawm cov hlab plawv system
Mel yog hom teeb liab teeb liab nrog ntau lub zog.Los ntawm kev hloov pauv ntawm nws qhov zais cia, nws tuaj yeem xa cov ntaub ntawv ntawm ib puag ncig lub teeb ci mus rau cov ntaub so ntswg hauv lub cev, kom lawv cov haujlwm ua haujlwm tuaj yeem hloov mus rau qhov kev hloov pauv ntawm lub ntiaj teb sab nraud.Yog li ntawd, qib ntawm cov ntshav melatonin secretion tuaj yeem cuam tshuam lub sijhawm sib xws ntawm hnub thiab lub caij sib xws ntawm lub xyoo.Lub circadian thiab lub caij nyoog rhythms ntawm cov kab mob muaj feem cuam tshuam nrog lub sijhawm hloov pauv ntawm lub zog thiab cov pa oxygen ntawm cov hlab plawv thiab cov hlab ntsws.Kev ua haujlwm ntawm vascular system muaj qhov pom tseeb circadian thiab raws caij nyoog, nrog rau cov ntshav siab, lub plawv dhia, lub plawv dhia, renin angiotensin aldosterone, thiab lwm yam. Cov kev tshawb fawb pom tau tias qhov tshwm sim ntawm myocardial infarction thiab ischemic plawv kab mob tau nce txog thaum sawv ntxov, qhia tias cov pib ntawm lub sij hawm-nyob.Tsis tas li ntawd, ntshav siab thiab catecholamine txo qis thaum hmo ntuj.Mel feem ntau yog zais thaum hmo ntuj, cuam tshuam rau ntau yam ntawm endocrine thiab kev ua haujlwm lom neeg.Kev sib raug zoo ntawm Mel thiab cov hlab ntsha tuaj yeem lees paub los ntawm cov txiaj ntsig kev sim hauv qab no: qhov nce ntawm Mel secretion thaum hmo ntuj yog qhov cuam tshuam tsis zoo nrog kev txo qis ntawm cov hlab plawv;Melatonin nyob rau hauv pineal caj pas tuaj yeem tiv thaiv lub plawv arrhythmia los ntawm ischemia-reperfusion raug mob, cuam tshuam rau kev tswj ntshav siab, tswj cov ntshav cerebral, thiab tswj cov lus teb ntawm cov hlab ntsha peripheral rau norepinephrine.Yog li ntawd, Mel tuaj yeem tswj cov hlab plawv.
Tsis tas li ntawd, melatonin kuj tswj cov kab mob ua pa, digestive system thiab tso zis.
Post lub sij hawm: Jun-22-2021