1,3-Dihydroxyacetone Production Methods and Applications introduction CAS 96-26-4

1,3-Dihydroxyacetone Taw Qhia

1,3-Dihydroxyacetone yog cov organic compound nrog cov qauv molecular C3H6O3, uas yog polyhydroxyketose thiab cov ketose yooj yim tshaj plaws.Cov tsos yog dawb hmoov siv lead ua, yooj yim soluble nyob rau hauv organic solvents xws li dej, ethanol, ether, thiab acetone.Lub melting point yog 75-80 ℃, thiab cov dej solubility yog> 250g / L (20 ℃).Nws muaj qab zib saj thiab ruaj khov ntawm pH 6.0.1,3-Dihydroxyacetone yog txo cov suab thaj.Tag nrho cov monosaccharides (tsuas yog muaj cov aldehyde dawb lossis ketone carbonyl pawg) muaj qhov txo qis.Dihydroxyacetone ua tau raws li cov xwm txheej saum toj no, yog li nws yog nyob rau hauv qeb ntawm kev txo cov suab thaj.

Muaj cov txheej txheem tshuaj synthesis thiab microbial fermentation txoj kev.Muaj peb txoj kev tshuaj lom neeg tseem ceeb rau 1,3-dihydroxyacetone: electrocatalysis, hlau catalytic oxidation, thiab formaldehyde condensation.Kev tsim tshuaj lom neeg ntawm 1,3-dihydroxyacetone tseem nyob rau hauv kev tshawb fawb theem.Kev tsim cov 1,3-dihydroxyacetone los ntawm txoj kev lom neeg muaj txiaj ntsig zoo: cov khoom lag luam siab, siab glycerol hloov pauv tus nqi thiab cov nqi qis.Kev tsim tawm ntawm 1,3-dihydroxyacetone hauv Suav teb thiab txawv teb chaws feem ntau yog siv txoj kev hloov pauv microbial ntawm glycerol.

Cov txheej txheem tshuaj synthesis

1. 1,3-dihydroxyacetone yog tsim los ntawm 1,3-dichloroacetone thiab ethylene glycol ua cov ntaub ntawv tseem ceeb los ntawm kev tiv thaiv carbonyl, etherification, hydrogenolysis, thiab hydrolysis.1,3-dichloroacetone thiab ethylene glycol yog rhuab thiab refluxed hauv toluene los tsim 2,2-dichloromethyl-1,3-dioxolane.Tom qab ntawd lawv hnov ​​​​mob nrog sodium benzylidene hauv N, N-dimethylformamide los tsim 2,2-dibenzyloxy-1,3-dioxolane, uas yog tom qab ntawd hydrogenated hauv Pd / C catalysis los ua ke 1,3-dioxolane-2,2-dimethanol, uas Tom qab ntawd hydrolyzed hauv hydrochloric acid los tsim 1,3-dihydroxyacetone.Cov khoom siv raw rau kev sib xyaw ua ke 1,3-dihydroxyacetone siv txoj kev no yooj yim kom tau, cov tshuaj tiv thaiv mob me me, thiab Pd / C catalyst tuaj yeem rov ua dua tshiab, uas muaj qhov tseem ceeb ntawm daim ntawv thov.

2. 1,3-dihydroxyacetone tau tsim los ntawm 1,3-dichloroacetone thiab methanol los ntawm kev tiv thaiv carbonyl, etherification, hydrolysis, thiab hydrolysis tshua.1,3-dichloroacetone reacts nrog ntau tshaj anhydrous methanol nyob rau hauv lub xub ntiag ntawm ib tug absorbent los tsim 2,2-dimethoxy-1,3-dichloropropane, uas yog ces rhuab nrog sodium benzylate nyob rau hauv N, N-dimethylformamide los tsim 2,2-dimethoxy -1,3-dibenzyloxypropane.Tom qab ntawd nws yog hydrogenated nyob rau hauv Pd / C catalysis los tsim 2,2-dimethoxy-1,3-propanediol, uas yog tom qab ntawd hydrolyzed hauv hydrochloric acid los tsim 1,3-dihydroxyacetone.Txoj kev no hloov cov khoom tiv thaiv carbonyl los ntawm ethylene glycol rau methanol, ua kom yooj yim rau kev sib cais thiab ntxuav cov khoom 1,3-dihydroxyacetone, uas muaj kev txhim kho tseem ceeb thiab daim ntawv thov tus nqi.

3. Synthesis ntawm 1,3-dihydroxyacetone siv acetone, methanol, chlorine los yog bromine ua cov ntaub ntawv tseem ceeb.Acetone, anhydrous methanol, thiab chlorine gas los yog bromine yog siv los tsim 2,2-dimethoxy-1,3-dichloropropane los yog 1,3-dibromo-2,2-dimethoxypropane los ntawm ib lub lauj kaub txheej txheem.Tom qab ntawd lawv tau etherified nrog sodium benzylate los tsim 2,2-dimethoxy-1,3-dibenzyloxypropane, uas yog tom qab ntawd hydrogenated thiab hydrolyzed los tsim 1,3-dihydroxyacetone.Txoj kev no muaj cov tshuaj tiv thaiv me me, thiab "ib lub lauj kaub" cov tshuaj tiv thaiv tsis txhob siv cov nqi kim thiab khaus khaus 1,3-dichloroacetone, ua rau tus nqi qis thiab muaj txiaj ntsig zoo rau kev txhim kho.

Daim ntawv thov

1,3-Dihydroxyacetone yog ib qho tshwm sim ketose uas yog biodegradable, noj tau, thiab tsis muaj tshuaj lom rau tib neeg lub cev thiab ib puag ncig.Nws yog ib tug multifunctional additive uas yuav siv tau nyob rau hauv cov tshuaj pleev ib ce, kws, thiab zaub mov industries.

Siv hauv kev lag luam tshuaj pleev ib ce

1,3-Dihydroxyacetone feem ntau yog siv los ua cov khoom xyaw hauv cov tshuaj pleev ib ce, tshwj xeeb tshaj yog cov tshuaj pleev thaiv hnub nrog cov teebmeem tshwj xeeb, uas tuaj yeem tiv thaiv cov evaporation ntau dhau ntawm daim tawv nqaij, thiab ua lub luag haujlwm hauv moisturizing, tiv thaiv tshav ntuj, thiab tiv thaiv UV hluav taws xob.Tsis tas li ntawd, pawg ketone ua haujlwm hauv DHA tuaj yeem hnov ​​​​mob nrog cov amino acids thiab cov amino pawg ntawm cov tawv nqaij keratin los tsim cov xim av polymer, ua rau tib neeg cov tawv nqaij tsim cov xim daj xim.Yog li ntawd, nws kuj tseem siv tau los ua ib qho simulant rau lub hnub raug tshav kom tau cov tawv nqaij xim av los yog xim av uas zoo ib yam li qhov tshwm sim ntawm kev raug tshav ntuj ntev, ua rau nws zoo nkauj.

Txhim kho cov nqaij ntshiv feem pua ​​ntawm cov npua

1,3-Dihydroxyacetone yog ib qho khoom nruab nrab ntawm cov piam thaj metabolism, ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm cov piam thaj metabolism, txo cov nqaij npua lub cev rog thiab txhim kho cov nqaij ntshiv feem pua.Cov neeg ua haujlwm tshawb fawb thiab thev naus laus zis hauv Nyij Pooj tau pom los ntawm kev sim uas ntxiv qee qhov DHA thiab sib xyaw ntawm pyruvate (calcium ntsev) hauv npua pub (hauv 3: 1 qhov hnyav piv) tuaj yeem txo cov rog ntawm cov nqaij npua rov qab los ntawm 12% rau 15%, thiab cov roj cov ntsiab lus ntawm ceg nqaij thiab cov nqaij leeg ntev tshaj plaws kuj raug txo qis, nrog rau kev nce hauv cov ntsiab lus protein.

Rau cov khoom noj ua haujlwm

Supplementing 1,3-dihydroxyacetone (tshwj xeeb tshaj yog ua ke nrog pyruvate) tuaj yeem txhim kho cov metabolism hauv lub cev thiab fatty acid oxidation, muaj peev xwm hlawv roj kom txo tau lub cev rog thiab ncua qhov hnyav nce (qhov hnyav poob), thiab txo qhov tshwm sim ntawm tus kab mob. kab mob ntsig txog.Nws tseem tuaj yeem txhim kho kev nkag siab ntawm insulin thiab txo qis cov roj cholesterol hauv cov ntshav los ntawm kev noj zaub mov muaj roj cholesterol.Kev noj qab haus huv ntev tuaj yeem ua rau nce kev siv cov ntshav qab zib thiab txuag cov leeg glycogen, Rau cov neeg ncaws pob, nws tuaj yeem txhim kho lawv cov kev ua haujlwm aerobic endurance.

Lwm yam kev siv

1,3-dihydroxyacetone tuaj yeem siv ncaj qha los ua cov tshuaj tiv thaiv kab mob.Piv txwv li, hauv kab lis kev cai qaib embryo, kev siv DHA tuaj yeem tiv thaiv tus kab mob ntawm tus kab mob qaib distemper, tua 51% mus rau 100% ntawm tus kab mob.Hauv kev lag luam tawv, DHA tuaj yeem siv los ua tus neeg sawv cev tiv thaiv rau cov khoom tawv.Tsis tas li ntawd, cov tshuaj tua kab mob feem ntau yog tsim los ntawm DHA tuaj yeem siv rau kev khaws cia thiab khaws cov txiv hmab txiv ntoo thiab zaub, cov khoom siv dej, thiab cov khoom noj nqaij.