Khoom siv: 2-phenylacetamide
Cov mis mos molecular: C8H9NO
Molecular Luj: 135.17
Lub npe Askiv: Phenylacetamide
Cim: Dawb flake los yog nplooj zoo li cov muaju.Mp 157-158 ℃, bp 280-290 ℃ (decomposition).Soluble hauv dej kub thiab ethanol, me ntsis soluble hauv dej txias, ether, thiab benzene.
Kev Siv: Cov tshuaj nruab nrab xws li penicillin thiab phenobarbital.Nws kuj yog siv rau kev npaj ntawm phenylacetic acid, txuj lom, thiab tshuaj tua kab.
Method 1) Masuko F, Katsura T.US 4536599A1.1985.
Ntxiv 117.2 g (1.0 mol) ntawm phenylacetonitrile (2), 56.1 g ntawm 25% poov tshuaj hydroxide tov, 291.5 g ntawm 35% hydrogen peroxide aqueous tov, 1.78 g ntawm benzyltrithylammonium chloride, thiab 351.5 g ntawm isopropanol.Do thiab hnov mob ntawm 50 ℃ rau 4 teev.Tom qab cov tshuaj tiv thaiv tiav lawm, isopropanol yog evaporated nyob rau hauv lub siab txo, txias, lim, ntxuav nrog dej, thiab qhuav kom tau cov compound (1) 128.5 g, mp 155 ℃, nrog ib tug yield ntawm 95%.
Method 2) Furniss BS, Hannaford AJ, Rogers V, et al.Vogel's Textbook of Practical Chemistry.Longman London thiab New York.Fourth edition, 1978: 518.
Ntxiv 100 g (0.85 mol) ntawm phenylacetonitrile (2) thiab 400 mL ntawm concentrated hydrochloric acid rau cov tshuaj tiv thaiv hwj.Nyob rau hauv stirring, react ntawm 40 ℃ li 40 feeb, thiab nce qhov kub ntawm 50 ℃.Txuas ntxiv mus rau 30 feeb.Txias rau 15 ℃ thiab ntxiv 400 mL dej txias distilled dropwise.Txias nyob rau hauv ib tug dej khov da dej, lim tawm crystals.Ntxiv cov khoom rau 50 mL dej thiab do kom huv si kom tshem tawm phenylacetic acid.Lim thiab qhuav ntawm 50-80 ℃ kom tau 95 g ntawm phenylacetamide (1), mp 154-155 ℃, nrog cov txiaj ntsig ntawm 82%.Recrystallization nrog ethanol, mp156 ℃.
Post lub sij hawm: Apr-11-2023